HLA typing does not predict REM sleep behaviour disorder and hallucinations in Parkinson's disease
Corresponding Author
Marco Onofrj MD
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy
Neurofisiopatologia, Ospedale Civile Spirito Santo, via Fonte Romana, 65124 Pescara, ItalySearch for more papers by this authorAnna Lisa Luciano MD
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy
Search for more papers by this authorDiego Iacono MD, PhD
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy
Search for more papers by this authorAstrid Thomas MD, PhD
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy
Search for more papers by this authorFabrizio Stocchi MD
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy
Search for more papers by this authorFranco Papola PhD
Regional Center for Immunohaematology and Tissue Typing, National Council of Research, L'Aquila, Italy
Search for more papers by this authorDomenico Adorno MD
Regional Center for Immunohaematology and Tissue Typing, National Council of Research, L'Aquila, Italy
Search for more papers by this authorRocco Di Mascio MD, PhD
Institute of Medical Statistics. Università G. D'Annunzio, Chieti-Pescara, Italy
Search for more papers by this authorCorresponding Author
Marco Onofrj MD
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy
Neurofisiopatologia, Ospedale Civile Spirito Santo, via Fonte Romana, 65124 Pescara, ItalySearch for more papers by this authorAnna Lisa Luciano MD
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy
Search for more papers by this authorDiego Iacono MD, PhD
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy
Search for more papers by this authorAstrid Thomas MD, PhD
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy
Search for more papers by this authorFabrizio Stocchi MD
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy
Search for more papers by this authorFranco Papola PhD
Regional Center for Immunohaematology and Tissue Typing, National Council of Research, L'Aquila, Italy
Search for more papers by this authorDomenico Adorno MD
Regional Center for Immunohaematology and Tissue Typing, National Council of Research, L'Aquila, Italy
Search for more papers by this authorRocco Di Mascio MD, PhD
Institute of Medical Statistics. Università G. D'Annunzio, Chieti-Pescara, Italy
Search for more papers by this authorAbstract
HLA-DR2 haplotype and DQ1 DNA alleles, characterizing 90 to 100% of all narcoleptic patients, were found to be equally distributed in 20 Parkinson's disease (PD) patients with early hallucinations, rapid eye movement (REM) sleep-related behaviour disturbances (RBD), and sleep onset in REM (SOREM), and in 20 PD patients without hallucinations, despite 10 to 15 years of treatment, and no RBD or SOREM.
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