Volume 18, Issue 5 p. 467-486
SIC Committee Report

SIC Task Force appraisal of clinical diagnostic criteria for parkinsonian disorders

Irene Litvan MD

Corresponding Author

Irene Litvan MD

Movement Disorder Program, University of Louisville, Bldg A Rm 113, Louisville, KY 40205

Movement Disorder Program, University of Louisville, Bldg A Rm 113, Louisville, KY 40205Search for more papers by this author
Kailash P. Bhatia MDDavid J. Burn MDChristopher G. Goetz MDAnthony E. Lang MD, FRCP

Anthony E. Lang MD, FRCP

Search for more papers by this author
Ian McKeith MDNiall Quinn MDKapil D. Sethi MDCliff Shults MDGregor K. Wenning MD
First published: 23 April 2003
Citations: 755

Abstract

As there are no biological markers for the antemortem diagnosis of degenerative parkinsonian disorders, diagnosis currently relies upon the presence and progression of clinical features and confirmation depends on neuropathology. Clinicopathologic studies have shown significant false-positive and false-negative rates for diagnosing these disorders, and misdiagnosis is especially common during the early stages of these diseases. It is important to establish a set of widely accepted diagnostic criteria for these disorders that may be applied and reproduced in a blinded fashion. This review summarizes the findings of the SIC Task Force for the study of diagnostic criteria for parkinsonian disorders in the areas of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, and corticobasal degeneration. In each of these areas, diagnosis continues to rest on clinical findings and the judicious use of ancillary studies. © 2003 Movement Disorder Society