Comparison of dementia with Lewy bodies to Alzheimer's disease and Parkinson's disease with dementia
Corresponding Author
Enrique Noe MD, PhD
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Servicio de Daño Cerebral, Hospital Valencia al Mar, Valencia, Spain
Servicio de Daño Cerebral-Hospital NISA Valencia al Mar. C/ Rio Tajo no.1, Valencia, Spain 46011Search for more papers by this authorKaren Marder MD, MPH
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
Search for more papers by this authorKaren L. Bell MD
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
Search for more papers by this authorDiane M. Jacobs PhD
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
Search for more papers by this authorJennifer J. Manly PhD
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
Search for more papers by this authorYaakov Stern MD
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
Department Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
Search for more papers by this authorCorresponding Author
Enrique Noe MD, PhD
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Servicio de Daño Cerebral, Hospital Valencia al Mar, Valencia, Spain
Servicio de Daño Cerebral-Hospital NISA Valencia al Mar. C/ Rio Tajo no.1, Valencia, Spain 46011Search for more papers by this authorKaren Marder MD, MPH
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
Search for more papers by this authorKaren L. Bell MD
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
Search for more papers by this authorDiane M. Jacobs PhD
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
Search for more papers by this authorJennifer J. Manly PhD
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
Search for more papers by this authorYaakov Stern MD
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
Department Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
Search for more papers by this authorAbstract
We compared the clinical and neuropsychological pattern of dementia with Lewy bodies (DLB) to Alzheimer's disease (AD) and Parkinson's disease with dementia (PD-d). Sixteen patients clinically diagnosed with DLB were compared with two groups of patients with PD-d (n = 15) and AD (n = 16) matched for level of dementia. Isolated cognitive impairment was the most common form of presentation in AD (93.8%) and DLB (31.3%) groups, while parkinsonism was in 100% of PD-d subjects. Psychoses associated with cognitive impairment at the beginning of the disease were more frequent in DLB patients (31.3%) than in AD (6.3%) and PD-d (0%) groups. There were no significant differences in Unified Parkinson Disease Rating Scale motor-subscale scores between DLB and PD-d patients. DLB and PD-d patients performed significantly worse on attentional functions and better on memory tests than AD. DLB patients also showed lower scores than AD subjects on visual memory, visuoperceptive, and visuoconstructive tests. No significant differences were found between PD-d group and DLB subjects on any neuropsychological test. We were unable to find any differences in cognitive tasks between PD-d and DLB subjects. Clinical features and neuropsychological deficiencies of DLB (attentional, visuoperceptive, and visuoconstructive deficits) and PD (attentional deficits) compared to AD (amnesic syndrome) can contribute to accurate identification of these entities and to the understanding of the neuropathological and neurochemical substrate underlying these diseases. © 2003 Movement Disorder Society
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