Volume 16, Issue 6 p. 1023-1032
Article

[123I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy

Andrea Varrone MD

Corresponding Author

Andrea Varrone MD

Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

Dipartimento di Diagnostica per Immagini e Radioterapia Universitα Frederico II, via S. Pansini 5, 80131, Napoli, ItalySearch for more papers by this author
Kenneth L. Marek MD

Kenneth L. Marek MD

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut

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Danna Jennings MD

Danna Jennings MD

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut

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Robert B. Innis MD, PhD

Robert B. Innis MD, PhD

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

Veterans Administration Connecticut, West Haven, Connecticut

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John P. Seibyl MD

John P. Seibyl MD

Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

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First published: 07 November 2001
Citations: 126

Abstract

In vivo imaging of the dopamine transporter (DAT) with single photon emission computed tomography (SPECT) is a quantitative biomarker for Parkinson's disease (PD) onset and severity. This study has examined and compared the loss of striatal DAT in PD and multiple system atrophy (MSA) using [123I]β-CIT SPECT imaging.

One hundred and eighty-three patients (157 PD and 26 MSA) were studied. Clinical rating scales (Hoehn and Yahr stage and Unified Parkinson's Disease Rating Scale [UPDRS] scores) demonstrated that the MSA patients were more severely impaired than the PD patients. The striatal [123I]β-CIT SPECT uptake was markedly reduced in both the PD and MSA groups. In addition, MSA patients showed more symmetric DAT loss compared with the PD patients, consistent with the more symmetric clinical motor dysfunction observed in MSA. While the loss of DAT was significantly reduced in all regions in both MSA and PD, comparison of the relative loss of the DAT did not significantly improve diagnostic accuracy in distinguishing between PD and MSA. © 2001 Movement Disorder Society.