Three-dimensional stereotactic surface projection study of freezing of gait and brain perfusion image in Parkinson's disease
Corresponding Author
Hideaki Matsui MD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Department of Neurology, Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-ku, Osaka, 530-0005, JapanSearch for more papers by this authorFukashi Udaka MD, PhD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorTakafumi Miyoshi MD
Department of Psychosomatic Medicine, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorNarihiro Hara MD
Department of Radiology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorAkiko Tamaura MD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorMasaya Oda MD, PhD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorTamotsu Kubori MD, PhD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorKazuto Nishinaka MD, PhD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorMasakuni Kameyama MD, PhD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorCorresponding Author
Hideaki Matsui MD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Department of Neurology, Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-ku, Osaka, 530-0005, JapanSearch for more papers by this authorFukashi Udaka MD, PhD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorTakafumi Miyoshi MD
Department of Psychosomatic Medicine, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorNarihiro Hara MD
Department of Radiology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorAkiko Tamaura MD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorMasaya Oda MD, PhD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorTamotsu Kubori MD, PhD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorKazuto Nishinaka MD, PhD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorMasakuni Kameyama MD, PhD
Department of Neurology, Sumitomo Hospital, Osaka, Japan
Search for more papers by this authorAbstract
Gait disturbance is a cardinal symptom in patients with Parkinson's disease. Among the gait disturbances, freezing of gait is a unique and troublesome symptom, but its mechanism is unclear. We compared brain perfusion images using three-dimensional stereotactic surface projection analysis of N-isopropyl-p-123I iodoamphetamine single photon emission computed tomography between Parkinson's disease patients with freezing of gait and those without. Twenty-four cases (freezing of gait group) with Parkinson's disease with freezing of gait, and 31 Hoehn and Yahr stage-matched cases (no freezing of gait group) with Parkinson's disease without freezing of gait were studied. Bilateral Brodmann area 11 perfusion of the freezing of gait group decreased significantly compared to that of the no freezing of gait group. The Brodmann area 11 may play important roles in gait, and impairment in this region may have a close relationship with freezing of gait in Parkinson's disease. © 2005 Movement Disorder Society
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