Volume 20, Issue 11 p. 1515-1520

Brief Report

Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease

Kevin J. Klos MD,

Kevin J. Klos MD

Department of Neurology, Movement Disorder Division, Mayo Clinic, Rochester, Minnesota, USA

Search for more papers by this author

Keith A. Josephs MST, MD,

Corresponding Author

Keith A. Josephs MST, MD

[email protected]

Department of Neurology, Movement Disorder Division, Mayo Clinic, Rochester, Minnesota, USA

Department of Behavioral Neurology, Mayo Clinic, Rochester, Minnesota, USA

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905Search for more papers by this author

Joseph E. Parisi MD,

Joseph E. Parisi MD

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

Search for more papers by this author

Dennis W. Dickson MD,

Dennis W. Dickson MD

Department of Neuropathology, Mayo Clinic, Jacksonville, Florida, USA

Search for more papers by this author

Kevin J. Klos MD,

Kevin J. Klos MD

Department of Neurology, Movement Disorder Division, Mayo Clinic, Rochester, Minnesota, USA

Search for more papers by this author

Keith A. Josephs MST, MD,

Corresponding Author

Keith A. Josephs MST, MD

[email protected]

Department of Neurology, Movement Disorder Division, Mayo Clinic, Rochester, Minnesota, USA

Department of Behavioral Neurology, Mayo Clinic, Rochester, Minnesota, USA

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905Search for more papers by this author

Joseph E. Parisi MD,

Joseph E. Parisi MD

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

Search for more papers by this author

Dennis W. Dickson MD,

Dennis W. Dickson MD

Department of Neuropathology, Mayo Clinic, Jacksonville, Florida, USA

Search for more papers by this author

First published: 20 July 2005

https://doi.org/10.1002/mds.20604

Citations: 14

Share a link

Email
Facebook
x
LinkedIn
Reddit
Wechat

Abstract

We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co-occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration. © 2005 Movement Disorder Society

REFERENCES

1 Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998; 51: 1546–1554.
10.1212/WNL.51.6.1546
CASPubMedWeb of Science®Google Scholar
2 Brooks BR, Miller RG, Swash M, et al. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000; 1: 293–299.
10.1080/146608200300079536
CASPubMedWeb of Science®Google Scholar
3 Hughes AJ, Daniel SE, Lees AJ. Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology 2001; 57: 1497–1499.
10.1212/WNL.57.8.1497
CASPubMedWeb of Science®Google Scholar
4 Murakami N. Parkinsonism-dementia complex on Guam: overview of clinical aspects. J Neurol 1999; 246(Suppl.): 1116–1118.
Google Scholar
5 Neary D, Snowden JS, Mann DM. Cognitive change in motor neurone disease/amyotrophic lateral sclerosis (MND/ALS). J Neurol Sci 2000; 180: 15–20.
10.1016/S0022-510X(00)00425-1
CASPubMedWeb of Science®Google Scholar
6 Ghetti B, Hutton ML, Wszolek ZK. FTDP-17. In: DW Dickson, editor. Neurodegeneration: the molecular pathology of dementia and movement disorders. Basel: ISN Neuropath Press; 2003. p 86–102.
Google Scholar
7 Oyanagi K. ALS-PDC of Guam. In: DW Dickson, editor. Neurodegeneration: the molecular pathology of dementia and movement disorders. Basel: ISN Neuropath Press; 2003. p 137–142.
Google Scholar
8 Lowe J, Rossor M. Frontotemporal lobar degeneration. In: DW Dickson, editor. Neurodegeneration: the molecular pathology of dementia and movement disorders. Basel: ISN Neuropath Press; 2003. p 342–348.
Google Scholar
9 Low PA. Autonomic nervous system function. J Clin Neurophysiol 1993; 10: 14–27.
CASGoogle Scholar
10 Fealey RD. Thermoregulatory sweat test. In: PA Low, editor. Clinical autonomic disorders: evaluation and management. Boston: Little, Brown; 1993. p 217.
Google Scholar
11 Josephs KA, Parisi JE, Dickson DW. Idiopathic Parkinson's disease with motor neuron disease. Brain Pathol 2003; 13: S58.
Google Scholar
12 Williams TL, Shaw PJ, Lowe J, Bates D, Ince PG. Parkinsonism in motor neuron disease: case report and literature review. Acta Neuropathol 1995; 89: 275–283.
10.1007/BF00309344
CASPubMedWeb of Science®Google Scholar
13 Qureshi AI, Wilmot G, Dihenia B, Scheider JA, Krendel DA. Motor neuron disease with Parkinsonism. Arch Neurol 1996; 53: 987–991.
10.1001/archneur.1996.00550100061015
CASPubMedWeb of Science®Google Scholar
14 Liang TW, Forman MS, Duda JE, McCluskey L, Trojanowski JQ, Siderowf A. Multiple pathologies in a patient with a progressive neurodegenerative syndrome. J Neurol Neurosurg Psychiatry 2005; 76: 252–255.
10.1136/jnnp.2004.039479
PubMedWeb of Science®Google Scholar
15 Piao YS, Wakabayashi K, Hayashi S, Yoshimoto M, Takahashi H. Aggregation of alpha-synuclein/NACP in the neuronal and glial cells in diffuse Lewy body disease: a survey of six patients. Clin Neuropathol 2000; 19: 163–169.
CASPubMedWeb of Science®Google Scholar
16 Togo T, Sahara N, Yen SH, et al. Argyrophilic grain disease is a sporadic 4-repeat tauopathy. J Neuropathol Exp Neurol 2002; 61: 547–556.
10.1093/jnen/61.6.547
CASPubMedWeb of Science®Google Scholar
17 Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Alpha-synuclein in Lewy bodies. Nature 1997; 388: 839–840.
10.1002/ana.67
CASPubMedWeb of Science®Google Scholar

Citing Literature

Volume20, Issue11

November 2005

Pages 1515-1520

Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease

Abstract

REFERENCES

Citing Literature

References

Information

RESOURCES

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease

Abstract

REFERENCES

Citing Literature

References

Related

Information

RESOURCES