Striatal dopa and glucose metabolism in PD patients with freezing of gait
Corresponding Author
Anna L. Bartels MD
Neurology Department of the University Medical Center Groningen, The Netherlands
University of Groningen, University Medical Center Groningen (UMCG), Department of Neurology, POB 30001, 9700 RB Groningen, The NetherlandsSearch for more papers by this authorBauke M. de Jong MD, PhD
Neurology Department of the University Medical Center Groningen, The Netherlands
Search for more papers by this authorNir Giladi MD
Neurology Department of the Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv, Israel
Search for more papers by this authorJoanna D. Schaafsma MD
Neurology Department of the University Medical Center Groningen, The Netherlands
Search for more papers by this authorR. Paul Maguire PhD
Neurology Department of the University Medical Center Groningen, The Netherlands
Search for more papers by this authorLammy Veenma
Neurology Department of the University Medical Center Groningen, The Netherlands
Search for more papers by this authorJan Pruim MD
PET Centre of the University Medical Center Groningen, The Netherlands
Search for more papers by this authorYacov Balash MD
Neurology Department of the Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv, Israel
Search for more papers by this authorMoussa B.H. Youdim MD
Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases, Technion-Faculty of Medicine, Haifa, Israel
Search for more papers by this authorKlaus L. Leenders MD, PhD
Neurology Department of the University Medical Center Groningen, The Netherlands
Search for more papers by this authorCorresponding Author
Anna L. Bartels MD
Neurology Department of the University Medical Center Groningen, The Netherlands
University of Groningen, University Medical Center Groningen (UMCG), Department of Neurology, POB 30001, 9700 RB Groningen, The NetherlandsSearch for more papers by this authorBauke M. de Jong MD, PhD
Neurology Department of the University Medical Center Groningen, The Netherlands
Search for more papers by this authorNir Giladi MD
Neurology Department of the Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv, Israel
Search for more papers by this authorJoanna D. Schaafsma MD
Neurology Department of the University Medical Center Groningen, The Netherlands
Search for more papers by this authorR. Paul Maguire PhD
Neurology Department of the University Medical Center Groningen, The Netherlands
Search for more papers by this authorLammy Veenma
Neurology Department of the University Medical Center Groningen, The Netherlands
Search for more papers by this authorJan Pruim MD
PET Centre of the University Medical Center Groningen, The Netherlands
Search for more papers by this authorYacov Balash MD
Neurology Department of the Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv, Israel
Search for more papers by this authorMoussa B.H. Youdim MD
Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases, Technion-Faculty of Medicine, Haifa, Israel
Search for more papers by this authorKlaus L. Leenders MD, PhD
Neurology Department of the University Medical Center Groningen, The Netherlands
Search for more papers by this authorAbstract
In Parkinson's disease (PD), freezing suggests sudden and transient blocks of motor behavior during initiating or continuous repetitive movements. Its underlying pathophysiology remains unclear. The objective of this study is to compare striatal dopamine metabolism and cerebral glucose metabolism between PD patients with and without freezing of gait (FOG). A total of 10 PD patients with FOG at off and 7 PD patients without FOG underwent brain positron emission tomography with 18[F]-6-fluoro-levodopa (FDOPA) and 18[F]-fluordesoxyglucose (FDG). Striatum decarboxylase activity was expressed by metabolic influx constants of the striatum related to the occipital lobe (Kocc). FDG uptake in caudate and putamen was normalized to global FDG uptake. Region of interest (ROI) analysis of striatal regions was used, as well as voxel-based analysis by statistical parametric mapping (SPM). ROI analysis did not reveal differences in striatal FDOPA and FDG uptake between the groups. SPM showed lower putaminal FDOPA uptake (P = 0.05 uncorrected) with increased FDG uptake (P = 0.01 uncorrected) in freezing PD, whereas caudate uptake of the two tracers was reduced. Freezing-related cortical FDG decrease was found in (right) parietal regions. In conclusion, in freezing PD, caudate uptake of FDG and FDOPA was reduced, whereas putamen FDOPA decrease was associated with FDG increase. Right hemisphere circuitry seemed to be more affected in freezing patients. © 2006 Movement Disorder Society
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