PET evidence of central GABAergic changes in stiff-person syndrome†
Corresponding Author
Daniela Perani MD
Istituto Nazionale di Neuroscienze, Vita-Salute San Raffaele University, Milan, Italy
Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, ItalySearch for more papers by this authorValentina Garibotto MD
Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
Milano-Bicocca University, Department of Nuclear Medicine, Milan, Italy
Search for more papers by this authorAndrea Panzacchi MD
Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
Consiglio Nazionale delle Ricerche, Istituto di Bioimmagini e Fisiologia Molecolare, Milan, Italy
Search for more papers by this authorRosa Maria Moresco MSc
Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
Milano-Bicocca University, Department of Nuclear Medicine, Milan, Italy
Consiglio Nazionale delle Ricerche, Istituto di Bioimmagini e Fisiologia Molecolare, Milan, Italy
Search for more papers by this authorPaola Ortelli MSc
Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
Search for more papers by this authorMassimo Corbo MD
University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Department of Neurology, Milan, Italy
Search for more papers by this authorFerruccio Fazio MD
Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
Milano-Bicocca University, Department of Nuclear Medicine, Milan, Italy
Consiglio Nazionale delle Ricerche, Istituto di Bioimmagini e Fisiologia Molecolare, Milan, Italy
Search for more papers by this authorFranco Folli MD
Division of Diabetes, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
Search for more papers by this authorCorresponding Author
Daniela Perani MD
Istituto Nazionale di Neuroscienze, Vita-Salute San Raffaele University, Milan, Italy
Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, ItalySearch for more papers by this authorValentina Garibotto MD
Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
Milano-Bicocca University, Department of Nuclear Medicine, Milan, Italy
Search for more papers by this authorAndrea Panzacchi MD
Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
Consiglio Nazionale delle Ricerche, Istituto di Bioimmagini e Fisiologia Molecolare, Milan, Italy
Search for more papers by this authorRosa Maria Moresco MSc
Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
Milano-Bicocca University, Department of Nuclear Medicine, Milan, Italy
Consiglio Nazionale delle Ricerche, Istituto di Bioimmagini e Fisiologia Molecolare, Milan, Italy
Search for more papers by this authorPaola Ortelli MSc
Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
Search for more papers by this authorMassimo Corbo MD
University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Department of Neurology, Milan, Italy
Search for more papers by this authorFerruccio Fazio MD
Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
Milano-Bicocca University, Department of Nuclear Medicine, Milan, Italy
Consiglio Nazionale delle Ricerche, Istituto di Bioimmagini e Fisiologia Molecolare, Milan, Italy
Search for more papers by this authorFranco Folli MD
Division of Diabetes, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
Search for more papers by this authorThese data were presented at the 58th Meeting of the American Academy of Neurology, 2006, and published in Abstract form, Neurology, vol. 66 (S2), page A134.
Abstract
We measured expression of central nervous system GABA-A receptors with 11C-flumazenil (11C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced 11C-FMZ binding potential (BP) in motor-premotor cortex, and increased 11C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms. © 2007 Movement Disorder Society
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