Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; Study using nonmotor symptoms questionnaire in 545 patients
Pablo Martinez-Martin PhD, MD
Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Search for more papers by this authorAnthony H.V. Schapira FRCP, MD, DSc, FmedSci
Department of Neurosciences, Royal Free Hospital Medical School and National Hospital for Neurology, Neurosurgery, Queen Square, London, United Kingdom
Search for more papers by this authorFabrizio Stocchi MD
Department of Neurology, IRCCS San Raffaele Roma, Italy
Search for more papers by this authorPer Odin MD
Department of Neurology, Klinikum-Bremerhaven Reinkenheide, Germany
Search for more papers by this authorGraeme MacPhee FRCP
Department of Care of the Elderly/Gerontology, Southern General Hospital, Glasgow
Search for more papers by this authorRichard G. Brown PhD
Department of Psychology, Institute of Psychiatry, King's College London, London, United Kingdom
Search for more papers by this authorYogini Naidu BSc, RGN
Department of Neurology, University Hospital Lewisham, London, United Kingdom
Search for more papers by this authorLisa Clayton BSC
Department of Neurology, Guy's King's and St. Thomas' School of Medicine, London, United Kingdom
Search for more papers by this authorKazuo Abe MD
Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan
Search for more papers by this authorYoshio Tsuboi MD
Department of Neurology, Fukuoka University, Fukuoka, Japan
Search for more papers by this authorDough MacMahon FRCP
Department of Medicine/Care of the Elderly, Camborne-Redruth Hospital, Redruth,Cornwall, United Kingdom
Search for more papers by this authorPaolo Barone MD
Department of Neurology, University of Napoli, Italy
Search for more papers by this authorMartin Rabey MD
Department of Neurology, Assaf Harofeh Medical Center, School of Medicine, Tel-Aviv University, Zerifin, Israel
Search for more papers by this authorUbaldo Bonuccelli MD
Department of Neurology, University of Pisa, Pisa, Italy
Search for more papers by this authorAlison Forbes RGN
Department of Clinical Neurosciences King's College Hospital, London, United Kingdom
Search for more papers by this authorKieran Breen MRCP
Research and Development Division, The UK Parkinson's Disease Society, London, United Kingdom
Search for more papers by this authorSusanne Tluk RGN
Department of Neurology, University Hospital Lewisham, London, United Kingdom
Search for more papers by this authorC. Warren Olanow MD
Department of Neurosciences, The Mount Sinai School of Medicine, New York
Search for more papers by this authorSue Thomas RGN
Department of Nursing, Royal College of Nursing, London, United Kingdom
Search for more papers by this authorDavid Rye MD
Department of Neurology, Emory University, Atlanta, GA
Search for more papers by this authorAnnette Hand RGN, MSc
Department of Medicine, North Tyneside General Hospital, North Shields, United Kingdom
Search for more papers by this authorAdrian J. Williams FRCP
Lane-Fox Sleep Centre, St. Thomas' Hospital, London, United Kingdom
Search for more papers by this authorWilliam Ondo MD
Department of Neurology, Baylor College of Medicine, Houston, Texas
Search for more papers by this authorCorresponding Author
K. Ray Chaudhuri MD, FRCP, DSc
Department of Clinical Neurosciences, National Parkinson Foundation Centre of Excellence, Kings College Hospital, University Hospital Lewisham, Guy's King's and St. Thomas' School of Medicine, London, United Kingdom
Movement Disorders Unit, 9th Floor Ruskin Wing, King's College Hospital, Denmark Hill, London SE5 9RS, United KingdomSearch for more papers by this authorPablo Martinez-Martin PhD, MD
Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Search for more papers by this authorAnthony H.V. Schapira FRCP, MD, DSc, FmedSci
Department of Neurosciences, Royal Free Hospital Medical School and National Hospital for Neurology, Neurosurgery, Queen Square, London, United Kingdom
Search for more papers by this authorFabrizio Stocchi MD
Department of Neurology, IRCCS San Raffaele Roma, Italy
Search for more papers by this authorPer Odin MD
Department of Neurology, Klinikum-Bremerhaven Reinkenheide, Germany
Search for more papers by this authorGraeme MacPhee FRCP
Department of Care of the Elderly/Gerontology, Southern General Hospital, Glasgow
Search for more papers by this authorRichard G. Brown PhD
Department of Psychology, Institute of Psychiatry, King's College London, London, United Kingdom
Search for more papers by this authorYogini Naidu BSc, RGN
Department of Neurology, University Hospital Lewisham, London, United Kingdom
Search for more papers by this authorLisa Clayton BSC
Department of Neurology, Guy's King's and St. Thomas' School of Medicine, London, United Kingdom
Search for more papers by this authorKazuo Abe MD
Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan
Search for more papers by this authorYoshio Tsuboi MD
Department of Neurology, Fukuoka University, Fukuoka, Japan
Search for more papers by this authorDough MacMahon FRCP
Department of Medicine/Care of the Elderly, Camborne-Redruth Hospital, Redruth,Cornwall, United Kingdom
Search for more papers by this authorPaolo Barone MD
Department of Neurology, University of Napoli, Italy
Search for more papers by this authorMartin Rabey MD
Department of Neurology, Assaf Harofeh Medical Center, School of Medicine, Tel-Aviv University, Zerifin, Israel
Search for more papers by this authorUbaldo Bonuccelli MD
Department of Neurology, University of Pisa, Pisa, Italy
Search for more papers by this authorAlison Forbes RGN
Department of Clinical Neurosciences King's College Hospital, London, United Kingdom
Search for more papers by this authorKieran Breen MRCP
Research and Development Division, The UK Parkinson's Disease Society, London, United Kingdom
Search for more papers by this authorSusanne Tluk RGN
Department of Neurology, University Hospital Lewisham, London, United Kingdom
Search for more papers by this authorC. Warren Olanow MD
Department of Neurosciences, The Mount Sinai School of Medicine, New York
Search for more papers by this authorSue Thomas RGN
Department of Nursing, Royal College of Nursing, London, United Kingdom
Search for more papers by this authorDavid Rye MD
Department of Neurology, Emory University, Atlanta, GA
Search for more papers by this authorAnnette Hand RGN, MSc
Department of Medicine, North Tyneside General Hospital, North Shields, United Kingdom
Search for more papers by this authorAdrian J. Williams FRCP
Lane-Fox Sleep Centre, St. Thomas' Hospital, London, United Kingdom
Search for more papers by this authorWilliam Ondo MD
Department of Neurology, Baylor College of Medicine, Houston, Texas
Search for more papers by this authorCorresponding Author
K. Ray Chaudhuri MD, FRCP, DSc
Department of Clinical Neurosciences, National Parkinson Foundation Centre of Excellence, Kings College Hospital, University Hospital Lewisham, Guy's King's and St. Thomas' School of Medicine, London, United Kingdom
Movement Disorders Unit, 9th Floor Ruskin Wing, King's College Hospital, Denmark Hill, London SE5 9RS, United KingdomSearch for more papers by this authorAbstract
2006, there was, no single instrument (questionnaire or scale) for attempting a comprehensive assessment of the wide range of nonmotor symptoms (NMS) of Parkinson's disease (PD). The PD nonmotor group, a multidisciplinary group of experts including patient group representatives developed and validated the NMS screening questionnaire (NMSQuest) comprising 30 items. The NMSQuest is a self completed screening tool designed to draw attention to the presence of NMS. In this paper, we present the results gathered from 545 patients using the definitive version of the NMSQuest highlighting the prevalence of the wide range of NMS flagged in the NMSQuest from consecutive PD patients in an international setting. © 2007 Movement Disorder Society
REFERENCES
- 1 Schrag A, Jahanshahi M, Quinn N. What contributes to quality of life in patients with Parkinson's disease? J Neurol Neurosurg Psychiatry 2000; 69: 308–312.
- 2 Chaudhuri KR, Healy DG, Schapira AH. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol 2006; 5: 235–245.
- 3 The National Institute for Clinical Excellence (NICE). Clinical guideline 35. Chapter 9. Parkinson's disease, June 2006 http://www.nice.org.uk/
- 4 Chaudhuri KR, Martinez-Martin P, Schapira AHV, et al. An international multicentre pilot study of the the first comprehensive self-completed non motor symptoms questionnaire for Parkinson's disease: the NMSQuest study. Mov Disord 2006; 21: 916–923.
- 5 Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55: 181–184.
- 6 Fisk JD, Brown MG, Sketris IS, Metz LM, Murray TJ, Stadnyk KJ. A comparison of health utility measures for the evaluation of multiple sclerosis treatments. J Neurol Neurosurg Psychiatry 2005; 76: 58–63.
- 7 Shulman LM, Taback RL, Rabinstein AA, Weiner WJ. Non-recognition of depression and other non-motor symptoms in Parkinson's disease. Parkinsonism Relat Disord 2002; 8: 193–197.
- 8 Hely MA, Morris JGL, Reid WGJ, Trafficante R. Sydney multicenter study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years. Mov Disord 2005; 20: 190–199.
- 9 Aarsland D, Larsen JP, Tandberg E, Laake K. Predictors of nursing home placement in Parkinson's disease: a population-based, prospective study. J Am Geriatr Soc 2000; 48: 938–942.
- 10 Schrag A, Jahanshahi M, Quinn N. What contributes to quality of life in patients with Parkinson's disease? J Neurol Neurosurg Psychiatry 2000; 69: 308–312.
- 11 Grosset D, Taurah L, Burn DJ, et al. A multicentre longitudinal observational study of changes in self reported health status in people with Parkinson's disease left untreated at diagnosis. J Neurol Nuerosurg Psychiatry 2007; 78: 465–469.
- 12 Stacy M, Bowron A, Guttman M, et al. Identification of motor and non motor wearing off in Parkinson's disease: comparison of a patient questionnaire versus a clinician assessment. Mov Disord 2005; 20: 726–733.
- 13
Muzerengi S,
Lewis H,
Edwrads M,
Kipps E,
Bahl A,
Martinez-Martin P,
Chaudhuri KR.
Non motor symptoms in Parkinson's disease: an underdiagnosed problem.
Ageing Health
2006;
2:
967–982.
10.2217/1745509X.2.6.967 Google Scholar
- 14 Olanow CW, Watts RL, Koller WC. An algorithm (decision tree) for the management of Parkinson's disease (2001): treatment guidelines. Neurology 2001; 56 (Suppl 5): S1–S88.
- 15 Burn DJ. Beyond the iron mask; towards better recognition and treatment of depression associated with Parkinson's disease. Mov Disord 2002; 17: 445–454.
- 16 Okun M, Walter BL, McDonald WM, Tenover JL, Green J, Juncos JL, DeLong MR. Beneficial effects of testosterone replacement for the non motor symptoms of Parkinson's disease. Arch Neurol 2002; 59: 1750–1753.