Volume 25, Issue 12 p. 1916-1923
Research Article

Putaminal magnetic resonance imaging features at various magnetic field strengths in multiple system atrophy

Hirohisa Watanabe MD

Hirohisa Watanabe MD

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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Mizuki Ito MD

Mizuki Ito MD

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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Hiroshi Fukatsu MD

Hiroshi Fukatsu MD

Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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Jo Senda MD

Jo Senda MD

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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Naoki Atsuta MD

Naoki Atsuta MD

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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Tomotsugu Kaga MD

Tomotsugu Kaga MD

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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Shigetaka Kato MD

Shigetaka Kato MD

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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Masahisa Katsuno MD

Masahisa Katsuno MD

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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Fumiaki Tanaka MD

Fumiaki Tanaka MD

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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Masaaki Hirayama MD

Masaaki Hirayama MD

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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Shinji Naganawa MD

Shinji Naganawa MD

Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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Gen Sobue MD

Corresponding Author

Gen Sobue MD

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550 JapanSearch for more papers by this author
First published: 08 September 2010
Citations: 31

Potential conflict of interest: Nothing to report.

Abstract

We delineated the effects of magnetic field strength on signal intensities to facilitate the specific findings of multiple system atrophy (MSA). Fifteen patients with probable MSA were imaged by 0.35T fast spin-echo (FSE), 1.5T FSE, and 3.0T FSE using a consistent protocol, testing all field strengths on the same day. Sixty patients with probable Parkinson's disease (PD) also underwent imaging. Moderate or marked hyperintensity at the dorsolateral outer putaminal margin, hyperintensity of the putaminal body, hypointensity relative to the globus pallidus at the dorsolateral putaminal margin, and infratentorial signal changes were evaluated as specific findings for MSA. As the field strength increased, the occurrence of hyperintensity both at the dorsolateral outer putaminal margin and of the putaminal body decreased, while the occurrence of hypointensity at the dorsolateral putaminal margin increased in MSA. The occurrence of uniform mild hyperintensity of the outer putaminal margin was evident in 7% at 0.35T, 40% at 1.5T, and 47% at 3.0T in MSA and in 5% at 0.35T, 60% at 1.5T, and 75% at 3.0T in PD. However, no PD patients showed hyperintensity at the dorsolateral outer putaminal margin and that of the putaminal body. Putaminal magnetic resonance imaging (MRI) findings in MSA were altered considerably by magnetic field strength. The severity and distribution of signal changes are important for assessing putaminal MRI findings in MSA. © 2010 Movement Disorders Society