Brief Report

Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease^†

Corresponding Author

Maurizio Gabrielli PhD

[email protected]

Internal Medicine Department, Catholic University of Sacred Heart, Rome, Italy

Internal Medicine, Gemelli Hospital, Catholic University of Sacred Heart, Gemelli, Hospital, Largo A. Gemelli 8, 00168 Rome, ItalySearch for more papers by this author

Patrizia Bonazzi PhD,

Patrizia Bonazzi PhD

Gastroenterology Department, Polytechnica University of Marche, Ancona, Italy

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Emidio Scarpellini MD,

Emidio Scarpellini MD

Internal Medicine Department, Catholic University of Sacred Heart, Rome, Italy

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Emanuele Bendia MD,

Emanuele Bendia MD

Gastroenterology Department, Polytechnica University of Marche, Ancona, Italy

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Ernesto C. Lauritano MD,

Ernesto C. Lauritano MD

Internal Medicine Department, Catholic University of Sacred Heart, Rome, Italy

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Alfonso Fasano MD,

Alfonso Fasano MD

Neuroscience Department, Catholic University of Sacred Heart, Rome, Italy

IRCCS Neuromed, Pozzilli, Isernia, Italy

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Maria G. Ceravolo PhD,

Maria G. Ceravolo PhD

Neuroscience Department, Polytechnica University of Marche, Ancona, Italy

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Marianna Capecci PhD,

Marianna Capecci PhD

Neuroscience Department, Polytechnica University of Marche, Ancona, Italy

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Anna Rita Bentivoglio MD,

Anna Rita Bentivoglio MD

Neuroscience Department, Catholic University of Sacred Heart, Rome, Italy

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Leandro Provinciali MD,

Leandro Provinciali MD

Neuroscience Department, Polytechnica University of Marche, Ancona, Italy

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Pietro A. Tonali MD,

Pietro A. Tonali MD

Neuroscience Department, Catholic University of Sacred Heart, Rome, Italy

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Antonio Gasbarrini MD,

Antonio Gasbarrini MD

Internal Medicine Department, Catholic University of Sacred Heart, Rome, Italy

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Maurizio Gabrielli PhD,

Corresponding Author

Maurizio Gabrielli PhD

[email protected]

Internal Medicine Department, Catholic University of Sacred Heart, Rome, Italy

Internal Medicine, Gemelli Hospital, Catholic University of Sacred Heart, Gemelli, Hospital, Largo A. Gemelli 8, 00168 Rome, ItalySearch for more papers by this author

Patrizia Bonazzi PhD,

Patrizia Bonazzi PhD

Gastroenterology Department, Polytechnica University of Marche, Ancona, Italy

Search for more papers by this author

Emidio Scarpellini MD,

Emidio Scarpellini MD

Internal Medicine Department, Catholic University of Sacred Heart, Rome, Italy

Search for more papers by this author

Emanuele Bendia MD,

Emanuele Bendia MD

Gastroenterology Department, Polytechnica University of Marche, Ancona, Italy

Search for more papers by this author

Ernesto C. Lauritano MD,

Ernesto C. Lauritano MD

Internal Medicine Department, Catholic University of Sacred Heart, Rome, Italy

Search for more papers by this author

Alfonso Fasano MD,

Alfonso Fasano MD

Neuroscience Department, Catholic University of Sacred Heart, Rome, Italy

IRCCS Neuromed, Pozzilli, Isernia, Italy

Search for more papers by this author

Maria G. Ceravolo PhD,

Maria G. Ceravolo PhD

Neuroscience Department, Polytechnica University of Marche, Ancona, Italy

Search for more papers by this author

Marianna Capecci PhD,

Marianna Capecci PhD

Neuroscience Department, Polytechnica University of Marche, Ancona, Italy

Search for more papers by this author

Anna Rita Bentivoglio MD,

Anna Rita Bentivoglio MD

Neuroscience Department, Catholic University of Sacred Heart, Rome, Italy

Search for more papers by this author

Leandro Provinciali MD,

Leandro Provinciali MD

Neuroscience Department, Polytechnica University of Marche, Ancona, Italy

Search for more papers by this author

Pietro A. Tonali MD,

Pietro A. Tonali MD

Neuroscience Department, Catholic University of Sacred Heart, Rome, Italy

Search for more papers by this author

Antonio Gasbarrini MD,

Antonio Gasbarrini MD

Internal Medicine Department, Catholic University of Sacred Heart, Rome, Italy

Search for more papers by this author

First published: 01 February 2011

https://doi.org/10.1002/mds.23566

Citations: 138

^†

Relevant conflict of interest: Nothing to report.

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Abstract

Background:

Parkinson's disease (PD) is associated with gastrointestinal motility abnormalities that could favor the occurrence of small intestinal bacterial overgrowth. The aim of the study was to assess the prevalence of small intestinal bacterial overgrowth in PD patients.

Methods:

Consecutive PD patients were enrolled. The controls were subjects without PD. All patients and controls underwent the glucose breath test to assess small intestinal bacterial overgrowth.

Results:

Forty-eight PD patients and 36 controls were enrolled. The prevalence of small intestinal bacterial overgrowth was significantly higher in PD patients than in controls (54.17% vs 8.33%; P < .0001; OR, 2.24; 95% CI, 3.50–48.24). Multivariate analysis showed Hoehn and Yahr stage (OR, 3.07; 95% CI, 1.14–8.27) and Unified PD Rating score (OR, 1.12; 95% CI, 1.02–1.23) were significantly associated with small intestinal bacterial overgrowth in PD patients.

Conclusions:

References

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Volume26, Issue5

April 2011

Pages 889-892

Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease^†

Abstract

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Results:

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Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease†

Abstract

Background:

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Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease^†