Should impulse control disorders and dopamine dysregulation syndrome be indications for deep brain stimulation and intestinal levodopa?
Corresponding Author
Michael S. Okun MD
University of Florida Center for Movement Disorders and Neurorestoration, Departments of Neurology and Neurosurgery, Gainesville, Florida
Correspondence to: Dr. Michael Okun, 100 S Newell Dr, Room L3-101, Department of Neurology, Gainesville, FL 32610; [email protected]Search for more papers by this authorDaniel Weintraub MD
Perelman School of Medicine at the University of Pennsylvania, Department of Psychiatry, Philadelphia, Pennsylvania
Parkinson's Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorCorresponding Author
Michael S. Okun MD
University of Florida Center for Movement Disorders and Neurorestoration, Departments of Neurology and Neurosurgery, Gainesville, Florida
Correspondence to: Dr. Michael Okun, 100 S Newell Dr, Room L3-101, Department of Neurology, Gainesville, FL 32610; [email protected]Search for more papers by this authorDaniel Weintraub MD
Perelman School of Medicine at the University of Pennsylvania, Department of Psychiatry, Philadelphia, Pennsylvania
Parkinson's Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania
Search for more papers by this authorRelevant conflicts of interest/financial disclosures: Nothing to report.
References
- 1Moum SJ, Price CC, Limotai N, et al. Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome. PLoS One 2012; 7: e29768.
- 2Voon V, Fernagut PO, Wickens J, et al. Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders. Lancet Neurol 2009; 8: 1140–1149.
- 3Thomas A, Bonanni L, Gambi F, et al. Pathological gambling in Parkinson disease is reduced by amantadine. Ann Neurol 2010; 68: 400–404.
- 4Okai D, Askey-Jones S, Samuel M, et al. Trial of CBT for impulse control behaviors affecting Parkinson patients and their caregivers. Neurology 2013; 80: 792–799.
- 5Witjas T, Baunez C, Henry JM, et al. Addiction in Parkinson's disease: impact of subthalamic nucleus deep brain stimulation. Mov Disord 2005; 20: 1052–1055.
- 6Bandini F, Primavera A, Pizzorno M, et al. Using STN DBS and medication reduction as a strategy to treat pathological gambling in Parkinson's disease. Parkinsonism Relat Disord 2007; 13: 369–371.
- 7Weintraub D. Dopamine and impulse control disorders in Parkinson's disease. Ann Neurol 2008; 64(Suppl 2): S93–S100.
- 8Steeves TD, Miyazaki J, Zurowski M, et al. Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study. Brain, 2009; 132(Pt 5): 1376–1385.
- 9Ceravolo R, Frosini D, Rossi C, et al. Impulse control disorders in Parkinson's disease: definition, epidemiology, risk factors, neurobiology and management. Parkinsonism Relat Disord;2009(Suppl 4): S111–S115.
- 10Sudhyadhom A, Bova FJ, Foote FD, et al. Limbic, associative, and motor territories within the targets for deep brain stimulation: potential clinical implications. Curr Neurol Neurosci Rep 2007; 7: 278–289.
- 11Frank MJ, Samanta J, Moustafa AA, et al. Hold your horses: impulsivity, deep brain stimulation, and medication in parkinsonism. Science 2007; 318(5854): 1309–1312.
- 12Ballanger B, et al. Stimulation of the subthalamic nucleus and impulsivity: release your horses. Ann Neurol 2009: 66: 817–824.
- 13Wu K, O'Sullivan S, Politis M, et al. Rewarding visual cues increase dopamine neurotransmission in Parkinson's patients with impulse control disorders: a PET study. J Neurol Neurosurg Psychiatr 2010; 81: e29–e30.
- 14O'Sullivan SS, Wu K, Politis M, et al. Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours. Brain 2011; 134(Pt 4): 969–978.
- 15Cilia R, van Eimeren T. Impulse control disorders in Parkinson's disease: seeking a roadmap toward a better understanding. Brain Struct Funct 2011; 216: 289–299.
- 16Evans AH, Strafella AP, Weintraub D, Stacy M. Impulsive and compulsive behaviors in Parkinson's disease. Mov Disord 2009; 24: 1561–1570.
- 17Cilia R, Cho SS, van Eimeren T, et al. Pathological gambling in patients with Parkinson's disease is associated with fronto-striatal disconnection: a path modeling analysis. Mov Disord 2011; 26: 225–233.
- 18Voon V, Pessiglione M, Brezing C, et al. Mechanisms underlying dopamine-mediated reward bias in compulsive behaviors. Neuron 2010; 65: 135–142.
- 19Rao H, Mamikonyan E, Detre JA, et al. Decreased ventral striatal activity with impulse control disorders in Parkinson's disease. Mov Disord 2010; 25: 1660–1669.
- 20Voon V, Gao J, Brezing C, et al. Dopamine agonists and risk: impulse control disorders in Parkinson's disease. Brain 2011; 134(Pt 5): 1438–1446.
- 21Frosini D, Pesaresi I, Cosottini M, et al. Parkinson's disease and pathological gambling: results from a functional MRI study. Mov Disord 2010; 25: 2449–2453.
- 22Rodriguez-Oroz MC, Lopez Azcarate J, Garcia-Garcia D, et al. Involvement of the subthalamic nucleus in impulse control disorders associated with Parkinson's disease. Brain 2011; 134(Pt 1): 36–49.
- 23Weintraub D, Nirenberg MJ. Impulse control and related disorders in Parkinson's disease. Neurodegener Dis 2013; 11: 63–71.
- 24Rabinak CA, Nirenberg MJ. Dopamine agonist withdrawal syndrome in Parkinson disease. Arch Neurol 2010; 67: 58–63.
- 25Bauer R, Pohl S, Klosterkotter J, et al. [Deep brain stimulation in the context of addiction-a literature-based systematic evaluation]. Fortschr Neurol Psychiatr 2008; 76: 396–401.
- 26Guo L, Zhou H, Wang R, et al. DBS of nucleus accumbens on heroin seeking behaviors in self-administering rats. Drug Alcohol Depend 2013; 129(1–2): 70–81.
- 27Halpern CH, Tekriwal A, Santollo J, et al. Amelioration of binge eating by nucleus accumbens shell deep brain stimulation in mice involves D2 receptor modulation. J Neurosci 2013; 33: 7122–7129.
- 28Halpern CH, Torres N, Hurting HI, et al. Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management. Acta Neurochir (Wien) 2011; 153(12): 2293–2306.
- 29Heldmann M, Berding G, Voges J, et al. Deep brain stimulation of nucleus accumbens region in alcoholism affects reward processing. PLoS One 2012; 7(5): e36572.
- 30Henderson MB, Green AI, Bradford PS, et al. Deep brain stimulation of the nucleus accumbens reduces alcohol intake in alcohol-preferring rats. Neurosurg Focus 2010; 29(2): E12.
- 31Kuhn J, Grunder TO, Bauer R, et al. Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring. Addict Biol 2011; 16(4): 620–623.
- 32Kuhn J, Moller M, Treppman JF, et al. Deep brain stimulation of the nucleus accumbens and its usefulness in severe opioid addiction. Mol Psychiatr 2013. DOI: 10.1038/mp.2012.196.
- 33Wu K, Politis M, Piccini P. Parkinson disease and impulse control disorders: a review of clinical features, pathophysiology and management. Postgrad Med J 2009; 85(1009): 590–596.
- 34Voon V, Krack P, Lang AE, et al. A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease. Brain 2008; 131(Pt 10): 2720–2728.
- 35Vilas DD, Pont-Sunyer C, Tolosa E. Impulse control disorders in Parkinson's disease. Parkinsonism Relat Disord, 2012. 18 Suppl 1: S80–S84.
- 36O'Sullivan SS, Evans AH, Lees AJ. Dopamine dysregulation syndrome: an overview of its epidemiology, mechanisms and management. CNS Drugs 2009; 23: 157–170.
- 37Lule D, Heimrath J, Pinkhardt EH, et al. Deep brain stimulation and behavioural changes: is comedication the most important factor? Neurodegener Dis 2012; 9: 18–24.
- 38Lhommee E, Klinger H, Thobois S, et al. Subthalamic stimulation in Parkinson's disease: restoring the balance of motivated behaviours. Brain 2012; 135(Pt 5): 1463–1477.
- 39Kim YE, Kim HJ, Kim HJ, et al. Impulse control and related behaviors after bilateral subthalamic stimulation in patients with Parkinson's disease. J Clin Neurosci 2013; 20: 964–969.
- 40Eusebio A, Witjas T, Cohen J, et al. Subthalamic nucleus stimulation and compulsive use of dopaminergic medication in Parkinson's disease. J Neurol Neurosurg Psychiatr 2013; 84: 868–874.
- 41Demetriades P, Rickards H, Cavanna AE. Impulse control disorders following deep brain stimulation of the subthalamic nucleus in Parkinson's disease: clinical aspects. Parkinsons Dis 2011 ( 2011), Article ID 658415; DOI: 10.4061/2011/658415.
- 42Shotbolt P, Moriarty J, Costello A, et al. Relationships between deep brain stimulation and impulse control disorders in Parkinson's disease, with a literature review. Parkinsonism Relat Disord 2012; 18: 10–16.
- 43Halbig TD, Tse W, Frisina PG, et al. Subthalamic deep brain stimulation and impulse control in Parkinson's disease. Eur J Neurol 2009; 16: 493–497.
- 44Follett KA, Weaver FM, Stern M, et al. Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease. N Engl J Med 2010; 362: 2077–2091.
- 45Zahodne LB, Susatia F, Bowers D, et al. Binge eating in Parkinson's disease: prevalence, correlates and the contribution of deep brain stimulation. J Neuropsychiatry Clin Neurosci 2011; 23: 56–62.
- 46Okun MS, Fernandez HH, Wu SS, et al. Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial. Ann Neurol 2009; 65: 586–595.
- 47Catalán MJ, de Pablo-Fernández E, Villanueva C, et al. Levodopa infusion improves impulsivity and dopamine dysregulation syndrome in Parkinson's disease. Mov Disord 2013: 28: 2007–2010.
- 48Weintraub D, Sohr M, Potenza MN, et al. Amantadine use associated with impulse control disorders in Parkinson disease in cross-sectional study. Ann Neurol 2010; 68: 963–968.
- 49Weintraub D, Koester J, Potenza MN, et al. Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients. Arch Neurol 2010; 67: 589–595.