Volume 32, Issue 5 p. 789-793
Brief Report

Minimal clinically important differences for the experiences of daily living parts of movement disorder society–sponsored unified Parkinson's disease rating scale

Krisztina Horváth MD

Krisztina Horváth MD

Doctoral School of Clinical Neuroscience, University of Pécs, Pécs, Hungary

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Zsuzsanna Aschermann MD

Zsuzsanna Aschermann MD

Doctoral School of Clinical Neuroscience, University of Pécs, Pécs, Hungary

Department of Neurology, University of Pécs, Pécs, Hungary

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 Márton Kovács BD

 Márton Kovács BD

Doctoral School of Clinical Neuroscience, University of Pécs, Pécs, Hungary

Department of Neurology, University of Pécs, Pécs, Hungary

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Attila Makkos BD

Attila Makkos BD

Doctoral School of Clinical Neuroscience, University of Pécs, Pécs, Hungary

Department of Neurology, University of Pécs, Pécs, Hungary

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 Márk Harmat MD

 Márk Harmat MD

Doctoral School of Clinical Neuroscience, University of Pécs, Pécs, Hungary

Department of Neurology, University of Pécs, Pécs, Hungary

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József Janszky MD, DSc

József Janszky MD, DSc

Department of Neurology, University of Pécs, Pécs, Hungary

MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary

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Sámuel Komoly MD, DSc

Sámuel Komoly MD, DSc

Department of Neurology, University of Pécs, Pécs, Hungary

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Kázmér Karádi MD

Kázmér Karádi MD

Doctoral School of Clinical Neuroscience, University of Pécs, Pécs, Hungary

Department of Behavioral Sciences, Universiyt of Pecs, Hungary

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Norbert Kovács MD, PhD

Corresponding Author

Norbert Kovács MD, PhD

Department of Neurology, University of Pécs, Pécs, Hungary

MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary

Correspondence to: Dr. Norbert Kovács, Department of Neurology, University of Pécs, 7623, Pécs, Rét utca 2, Hungary; E-mail: [email protected]Search for more papers by this author
First published: 20 February 2017
Citations: 65

Funding agencies: This study was supported by the OTKA PD103964 and Hungarian Brain Research Program (KTIA_13_NAP-A-II/10) government-based funds. N.K. was supported by the New National Excellence Program of the Ministry of Human Capacities, Hungary (ÚNKP-16-4-III).

Relevant conflicts of interest/financial disclosures: Nothing to report.

Full financial disclosures and author roles may be found in the online version of this article.

Abstract

Background: The minimal clinically important difference is the smallest change of scores clinically meaningful to patients.

Objectives: We aimed to calculate these threshold values in association with the International Parkinson and Movement Disorder Society UPDRS (MDS-UPDRS) Parts I and II and to evaluate the feasibility of the composite score of Part I and II (MDS-UPDRS I+II) as an outcome.

Methods: Nine hundred eighty-five paired investigations of 365 patients were reviewed, implementing three different techniques simultaneously.

Results: Based on the ordinal regression modeling, the MDS-UPDRS I+II score is an applicable outcome measure. Any improvement greater than 2.64 points or any worsening more than 2.45 points on MDS-UPDRS Part I represent a minimal, yet clinically meaningful change. In reference to Part II, the smallest changes considered clinically relevant were 3.05 and 2.51 points for improvement and deterioration, respectively. The thresholds for MDS-UPDRS I+II were 5.73 points for improvement and 4.70 points for worsening.

Conclusions: Our minimal clinically important difference thresholds can be utilized in clinical practice in judging clinical relevance. © 2016 International Parkinson and Movement Disorder Society