Deep brain stimulation treated dystonia-trajectory via status dystonicus
Elodie Nerrant MD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), Montpellier, France
Université Montpellier, 34000 Montpellier, France
Search for more papers by this authorVictoria Gonzalez MD, PhD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), Montpellier, France
Université Montpellier, 34000 Montpellier, France
Search for more papers by this authorChristophe Milesi MD, PhD
Université Montpellier, 34000 Montpellier, France
Département Pédiatrie néonatale et réanimations; Centre Hospitalier Régional Montpellier, Montpellier, France
Search for more papers by this authorXavier Vasques PhD
Laboratoire de Recherche en Neurosciences Cliniques (LRENC), Montpellier, France
IBM Systems, IBM, Montpellier, France
Search for more papers by this authorDiane Ruge MD, PhD
Department of Psychology and Neurosciences. Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Dortmund, Germany
Search for more papers by this authorThomas Roujeau MD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Université Montpellier, 34000 Montpellier, France
Search for more papers by this authorIsabel De Antonio Rubio
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), Montpellier, France
Université Montpellier, 34000 Montpellier, France
Search for more papers by this authorFabienne Cyprien MD, PhD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), Montpellier, France
Inserm U1061, Hôpital La Colombière, Montpellier, France
Search for more papers by this authorEmilie Chan Seng MD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Université Montpellier, 34000 Montpellier, France
INSERM U 1051, Institut des Neurosciences Montpellier, Montpellier, France
Search for more papers by this authorDiane Demailly
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Université Montpellier, 34000 Montpellier, France
Search for more papers by this authorAgathe Roubertie MD, PhD
Université Montpellier, 34000 Montpellier, France
Département de Neuropédiatrie, Centre Hospitalier Régional Montpellier, Montpellier, France
Search for more papers by this authorAlain Boularan MD
Université Montpellier, 34000 Montpellier, France
Anesthésie-Réanimation Gui de Chauliac, Centre Hospitalier Régional Montpellier, Montpellier, France
Search for more papers by this authorFréderic Greco MD
Université Montpellier, 34000 Montpellier, France
Anesthésie-Réanimation Gui de Chauliac, Centre Hospitalier Régional Montpellier, Montpellier, France
Search for more papers by this authorPierre-François Perrigault MD
Université Montpellier, 34000 Montpellier, France
Anesthésie-Réanimation Gui de Chauliac, Centre Hospitalier Régional Montpellier, Montpellier, France
Search for more papers by this authorGilles Cambonie MD, PhD
Université Montpellier, 34000 Montpellier, France
Département Pédiatrie néonatale et réanimations; Centre Hospitalier Régional Montpellier, Montpellier, France
Search for more papers by this authorPhilippe Coubes MD, PhD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), Montpellier, France
Université Montpellier, 34000 Montpellier, France
Search for more papers by this authorCorresponding Author
Laura Cif MD, PhD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), Montpellier, France
Université Montpellier, 34000 Montpellier, France
Correspondence to: Dr. Laura Cif, Département de Neurochirurgie, Centre Hospitalier Universitaire Montpellier, 80, Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France; E-mail: [email protected]Search for more papers by this authorElodie Nerrant MD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), Montpellier, France
Université Montpellier, 34000 Montpellier, France
Search for more papers by this authorVictoria Gonzalez MD, PhD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), Montpellier, France
Université Montpellier, 34000 Montpellier, France
Search for more papers by this authorChristophe Milesi MD, PhD
Université Montpellier, 34000 Montpellier, France
Département Pédiatrie néonatale et réanimations; Centre Hospitalier Régional Montpellier, Montpellier, France
Search for more papers by this authorXavier Vasques PhD
Laboratoire de Recherche en Neurosciences Cliniques (LRENC), Montpellier, France
IBM Systems, IBM, Montpellier, France
Search for more papers by this authorDiane Ruge MD, PhD
Department of Psychology and Neurosciences. Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Dortmund, Germany
Search for more papers by this authorThomas Roujeau MD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Université Montpellier, 34000 Montpellier, France
Search for more papers by this authorIsabel De Antonio Rubio
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), Montpellier, France
Université Montpellier, 34000 Montpellier, France
Search for more papers by this authorFabienne Cyprien MD, PhD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), Montpellier, France
Inserm U1061, Hôpital La Colombière, Montpellier, France
Search for more papers by this authorEmilie Chan Seng MD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Université Montpellier, 34000 Montpellier, France
INSERM U 1051, Institut des Neurosciences Montpellier, Montpellier, France
Search for more papers by this authorDiane Demailly
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Université Montpellier, 34000 Montpellier, France
Search for more papers by this authorAgathe Roubertie MD, PhD
Université Montpellier, 34000 Montpellier, France
Département de Neuropédiatrie, Centre Hospitalier Régional Montpellier, Montpellier, France
Search for more papers by this authorAlain Boularan MD
Université Montpellier, 34000 Montpellier, France
Anesthésie-Réanimation Gui de Chauliac, Centre Hospitalier Régional Montpellier, Montpellier, France
Search for more papers by this authorFréderic Greco MD
Université Montpellier, 34000 Montpellier, France
Anesthésie-Réanimation Gui de Chauliac, Centre Hospitalier Régional Montpellier, Montpellier, France
Search for more papers by this authorPierre-François Perrigault MD
Université Montpellier, 34000 Montpellier, France
Anesthésie-Réanimation Gui de Chauliac, Centre Hospitalier Régional Montpellier, Montpellier, France
Search for more papers by this authorGilles Cambonie MD, PhD
Université Montpellier, 34000 Montpellier, France
Département Pédiatrie néonatale et réanimations; Centre Hospitalier Régional Montpellier, Montpellier, France
Search for more papers by this authorPhilippe Coubes MD, PhD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), Montpellier, France
Université Montpellier, 34000 Montpellier, France
Search for more papers by this authorCorresponding Author
Laura Cif MD, PhD
Département de Neurochirurgie, Centre Hospitalier Régional Montpellier, France
Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), Montpellier, France
Université Montpellier, 34000 Montpellier, France
Correspondence to: Dr. Laura Cif, Département de Neurochirurgie, Centre Hospitalier Universitaire Montpellier, 80, Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France; E-mail: [email protected]Search for more papers by this authorPhilippe Coubes and Laura Cif are shared last authors.
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
ABSTRACT
Background: Status dystonicus (SD) is a life-threatening condition.
Objective and Methods: In a dystonia cohort who developed status dystonicus, we analyzed demographics, background dystonia phenomenology and complexity, trajectory previous to-, via status dystonicus episodes, and evolution following them.
Results: Over 20 years, 40 of 328 dystonia patients who were receiving DBS developed 58 status dystonicus episodes. Dystonia was of pediatric onset (95%), frequently complex, and had additional cognitive and pyramidal impairment (62%) and MRI alterations (82.5%); 40% of episodes occured in adults. Mean disease duration preceding status dystonicus was 10.3 ± 8 years. Evolution time to status dystonicus varied from days to weeks; however, 37.5% of patients exhibited progressive worsening over years. Overall, DBS was efficient in resolving 90% of episodes.
Conclusion: Status dystonicus is potentially reversible and a result of heterogeneous conditions with nonuniform underlying physiology. Recognition of the complex phenomenology, morphological alterations, and distinct patterns of evolution, before and after status dystonicus, will help our understanding of these conditions. © 2018 International Parkinson and Movement Disorder Society
Supporting Information
Additional Supporting Information may be found in the online version of this article.
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mds27357-sup-0001-suppinfo1.docx107.7 KB | Supplementary Information 1 |
mds27357-sup-0002-suppinfof1.tiff14.7 MB | Supplementary Information Figure 1 |
mds27357-sup-0003-suppinfof2.tiff269.5 KB | Supplementary Information Figure 2 |
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