Brief Report

Pallidal beta bursts in Parkinson's disease and dystonia

Roxanne Lofredi MD

Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité–Universitätsmedizin Berlin, Berlin, Germany

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Wolf-Julian Neumann MD,

Wolf-Julian Neumann MD

Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité–Universitätsmedizin Berlin, Berlin, Germany

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Christof Brücke MD, PhD,

Christof Brücke MD, PhD

Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité–Universitätsmedizin Berlin, Berlin, Germany

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Julius Huebl MD,

Julius Huebl MD

Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité–Universitätsmedizin Berlin, Berlin, Germany

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Joachim K. Krauss MD,

Joachim K. Krauss MD

Department of Neurosurgery, Medical School Hannover, Hannover, Germany

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Gerd-Helge Schneider MD,

Gerd-Helge Schneider MD

Department of Neurosurgery, Charité–Universitätsmedizin Berlin, Berlin, Germany

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Andrea A. Kühn MD,

Corresponding Author

Andrea A. Kühn MD

[email protected]

Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité–Universitätsmedizin Berlin, Berlin, Germany

Corresponding author: Prof. Dr. Andrea A. Kühn, Department of Neurology, Charité- Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin; [email protected]Search for more papers by this author

Roxanne Lofredi MD,

Roxanne Lofredi MD

Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité–Universitätsmedizin Berlin, Berlin, Germany

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Wolf-Julian Neumann MD,

Wolf-Julian Neumann MD

Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité–Universitätsmedizin Berlin, Berlin, Germany

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Christof Brücke MD, PhD,

Christof Brücke MD, PhD

Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité–Universitätsmedizin Berlin, Berlin, Germany

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Julius Huebl MD,

Julius Huebl MD

Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité–Universitätsmedizin Berlin, Berlin, Germany

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Joachim K. Krauss MD,

Joachim K. Krauss MD

Department of Neurosurgery, Medical School Hannover, Hannover, Germany

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Gerd-Helge Schneider MD,

Gerd-Helge Schneider MD

Department of Neurosurgery, Charité–Universitätsmedizin Berlin, Berlin, Germany

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Andrea A. Kühn MD,

Corresponding Author

Andrea A. Kühn MD

[email protected]

Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité–Universitätsmedizin Berlin, Berlin, Germany

First published: 15 November 2018

https://doi.org/10.1002/mds.27524

Citations: 27

Funding agencies: This work was supported by the German Research Foundation (Grant KFO 247) and the German Federal Ministry of Education and Research project ‘dystract’ (01GM1514D).

Relevant conflicts of interests/financial disclosures: Nothing to report.

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ABSTRACT

Background

Exaggerated beta power has been discussed as a disease-specific biomarker for Parkinson's disease (PD) and has recently been suggested to rely on prolonged bursts of subthalamic beta synchronization.

Objective

In this study, we test whether prolonged bursts are disease specific for beta activity in PD by comparison to oscillatory activity in dystonia.

Methods

Pallidal local field potentials were recorded from 5 PD patients ON and OFF dopaminergic medication and 5 dystonia patients. Synchronization of beta and low-frequency oscillations in bursts was compared between groups with respect to their duration, amplitude, and rate.

Results

Pallidal beta bursts were longer in PD-OFF than PD-ON or dystonia (P < .05). PD-ON and dystonia displayed similar beta burst dynamics. Low-frequency burst features showed no differences across groups.

Conclusions

Prolonged burst duration appears as a disease-specific feature for beta activity in PD across the basal ganglia. With dopaminergic medication, beta bursts in PD resemble those in dystonia, which supports the notion of short beta bursts as a physiological pattern. © 2018 International Parkinson and Movement Disorder Society

Supporting Information

References

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2Geng X, Zhang J, Jiang Y, et al. Comparison of oscillatory activity in subthalamic nucleus in Parkinson's disease and dystonia. Neurobiol Dis 2017; 98: 100-107. https://doi.org/10.1016/j.nbd.2016.12.006.
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Citing Literature

Volume34, Issue3

March 2019

Pages 420-424

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mds27524-sup-0001-FigureS1.tiff329.6 KB	Figure S1
mds27524-sup-0002-FigureS2.tiff1.5 MB	Figure S2
mds27524-sup-0003-FigureS3.tiff917.5 KB	Figure S3
mds27524-sup-0004-FigureS4.tiff119 KB	Figure S4

Pallidal beta bursts in Parkinson's disease and dystonia

ABSTRACT

Background

Objective

Methods

Results

Conclusions

Supporting Information

References

Citing Literature

References

Information

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Pallidal beta bursts in Parkinson's disease and dystonia

ABSTRACT

Background

Objective

Methods

Results

Conclusions

Supporting Information

References

Citing Literature

References

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