Toward a better definition of the restless legs syndrome
Corresponding Author
Dr. Arthur S. Walters
Group Organizer and Correspondent
The International Restless Legs Syndrome Study Group
Department of Neurology, CN 19, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903-0019, U.S.ASearch for more papers by this authorMichael S. Aldrich
University of Michigan, Ann Arbor, MI, U.S.A.
Search for more papers by this authorSonia Ancoli-Israel
University of California at San Diego and VAMC, San Diego, CA, U.S.A.
Search for more papers by this authorSudhansu Chokroverty
Robert Wood Johnson Medical School, New Brunswick, NJ and Lyons VA Medical Center, Lyons, NJ, U.S.A.
Search for more papers by this authorChristopher Earley
University of Michigan, Ann Arbor, MI, U.S.A.
Search for more papers by this authorBruce Ehrenberg
Tufts New England Medical Center, Boston, MA, U.S.A.
Search for more papers by this authorWayne Hening
Robert Wood Johnson Medical School, New Brunswick, NJ and Lyons VA Medical Center, Lyons, NJ, U.S.A.
Search for more papers by this authorNeil Kavey
Columbia Presbyterian Medical Center, New York City, NY, U.S.A.
Search for more papers by this authorJoseph Lipinski
University of Massachusetts, Worcester, MA, U.S.A.
Search for more papers by this authorWolfgang Oertel
Ludwig-Maximilians-Universitat, Munich, Germany
Search for more papers by this authorThomas Pollmächer
Max Planck Institute of Psychiatry, Munich, Germany
Search for more papers by this authorRenata Shafor
San Diego Sleep Disorders Center and Harbor View Medical Center, San Diego, CA, U.S.A.
Search for more papers by this authorRobert C. Smith
Michigan State University, East Lansing MI, U.S.A.
Search for more papers by this authorClaudia Trenkwalder
Ludwig-Maximilians-Universitat, Munich, Germany
Max Planck Institute of Psychiatry, Munich, Germany
Search for more papers by this authorArthur S. Walters
Robert Wood Johnson Medical School, New Brunswick, NJ and Lyons VA Medical Center, Lyons, NJ, U.S.A.
Search for more papers by this authorJ. Catesby Ware
Eastern Virginia Medical School and Sentara Norfolk General Hospital
Search for more papers by this authorCorresponding Author
Dr. Arthur S. Walters
Group Organizer and Correspondent
The International Restless Legs Syndrome Study Group
Department of Neurology, CN 19, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903-0019, U.S.ASearch for more papers by this authorMichael S. Aldrich
University of Michigan, Ann Arbor, MI, U.S.A.
Search for more papers by this authorSonia Ancoli-Israel
University of California at San Diego and VAMC, San Diego, CA, U.S.A.
Search for more papers by this authorSudhansu Chokroverty
Robert Wood Johnson Medical School, New Brunswick, NJ and Lyons VA Medical Center, Lyons, NJ, U.S.A.
Search for more papers by this authorChristopher Earley
University of Michigan, Ann Arbor, MI, U.S.A.
Search for more papers by this authorBruce Ehrenberg
Tufts New England Medical Center, Boston, MA, U.S.A.
Search for more papers by this authorWayne Hening
Robert Wood Johnson Medical School, New Brunswick, NJ and Lyons VA Medical Center, Lyons, NJ, U.S.A.
Search for more papers by this authorNeil Kavey
Columbia Presbyterian Medical Center, New York City, NY, U.S.A.
Search for more papers by this authorJoseph Lipinski
University of Massachusetts, Worcester, MA, U.S.A.
Search for more papers by this authorWolfgang Oertel
Ludwig-Maximilians-Universitat, Munich, Germany
Search for more papers by this authorThomas Pollmächer
Max Planck Institute of Psychiatry, Munich, Germany
Search for more papers by this authorRenata Shafor
San Diego Sleep Disorders Center and Harbor View Medical Center, San Diego, CA, U.S.A.
Search for more papers by this authorRobert C. Smith
Michigan State University, East Lansing MI, U.S.A.
Search for more papers by this authorClaudia Trenkwalder
Ludwig-Maximilians-Universitat, Munich, Germany
Max Planck Institute of Psychiatry, Munich, Germany
Search for more papers by this authorArthur S. Walters
Robert Wood Johnson Medical School, New Brunswick, NJ and Lyons VA Medical Center, Lyons, NJ, U.S.A.
Search for more papers by this authorJ. Catesby Ware
Eastern Virginia Medical School and Sentara Norfolk General Hospital
Search for more papers by this authorAbstract
A large International Restless Legs Syndrome (RLS) Study Group has been formed. As its first task, the group has taken upon itself the role of definig the clinical features of the RLS. As minimal criteria for diagnosis, the group proposes the following four features: (a) desire to move the extremities, often associated with paresthesias/dysesthesias; (b) motor restlessness; (c) worsening of symptoms at rest with at least temporary relief by activity, and (d) worsening of symptoms in the evening or night. Other features commonly seen in RLS include sleep disturbance, periodic limb movements in sleep and similar involuntary movements while awake, a normal neurological examination in the idiopathic from, a tendency for the symptoms to be worse in middle to older age, and, in some cases, a family history suggestive of an autosomal dominant mode of inheritance.
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