Bilateral subthalamic nucleus stimulation for severe Parkinson's disease
Corresponding Author
Dr. Patricia Limousin
Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, Grenoble
Department of Clinical and Biological Neurosciences, Clinique Neurologique, Centre Hospitalier Régional et Universitaire de Grenoble, BP 217 X, 38043 Grenoble Cedex 9, FranceSearch for more papers by this authorPierre Pollak
Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, Grenoble
Search for more papers by this authorAbdelhamid Benazzouz
Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, Grenoble
Search for more papers by this authorDominique Hoffmann
Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, Grenoble
Search for more papers by this authorJean Edmond Perret
Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, Grenoble
Search for more papers by this authorAlim-Louis Benabid
Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, Grenoble
Search for more papers by this authorCorresponding Author
Dr. Patricia Limousin
Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, Grenoble
Department of Clinical and Biological Neurosciences, Clinique Neurologique, Centre Hospitalier Régional et Universitaire de Grenoble, BP 217 X, 38043 Grenoble Cedex 9, FranceSearch for more papers by this authorPierre Pollak
Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, Grenoble
Search for more papers by this authorAbdelhamid Benazzouz
Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, Grenoble
Search for more papers by this authorDominique Hoffmann
Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, Grenoble
Search for more papers by this authorJean Edmond Perret
Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, Grenoble
Search for more papers by this authorAlim-Louis Benabid
Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, Grenoble
Search for more papers by this authorAbstract
Subthalamic nucleus (STN) lesions or high-frequency stimulations could improve parkinsonian symptoms in monkeys treated by MPTP. We have applied the procedure of chronic stimulation to the STN in severely disabled parkinsonian patients. This article presents the case of the first patient operated on bilaterally. Bilateral STN stimulation has greatly improved akinesia and rigidity. The benefit was maintained ≤15 months after surgery. Unilateral stimulation induced motor effects mainly in contralateral limbs. Further studies are needed to evaluate the value of this procedure in the treatment of Parkinson's disease.
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