Volume 12, Issue 3 p. 423-425
Brief Report

Long-term results with cisapride in Parkinson's disease

Dr. med. Wolfgang H. Jost

Corresponding Author

Dr. med. Wolfgang H. Jost

Departments of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany

Department of Neurology and Clinical Neurophysiology, Deutsche Klinik für Diagnostik, Aukammallee 33, D-65191 Wiesbaden, GermanySearch for more papers by this author
Klaus Schimrigk

Klaus Schimrigk

University of Saarland, Homburg/Saar, Germany

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First published: 04 November 2004
Citations: 36

Abstract

In this study, we examined whether there is a longterm effect of cisapride on colonic transit in Parkinson's disease. Twenty-five patients (11 women, 14 men; average age, 64.4 years; moderate symptoms) were studied and treated initially with cisapride, 5 mg, twice a day, and after the first week with cisapride, 10 mg, twice a day. Colonic transit was measured by radioopaque markers at various stages: after 1 week, 6 months, and 1 year. In untreated patients, transit took 131 h; after 1 week with cisapride, it was accelerated to 81 h. After 6 months, colonic transit time amounted to 99 and to 118 h, respectively, after 1 year. Cisapride seems to be highly effective initially. After 6 months, a significant but reduced effect was seen, and after 1 year, only a small effect could be demonstrated.